| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ajax | 15 | 11 | 3 | 1 | 48 | 2 | +46 | 36 |
| 2 | Feyenoord | 15 | 11 | 2 | 2 | 38 | 14 | +24 | 35 |
| 3 | PSV Eindhoven | 15 | 11 | 1 | 3 | 38 | 22 | +16 | 34 |
| 4 | Utrecht | 15 | 8 | 2 | 5 | 30 | 20 | +10 | 26 |
| 5 | Vitesse | 15 | 8 | 2 | 5 | 20 | 22 | -2 | 26 |
| 6 | Twente | 15 | 7 | 4 | 4 | 22 | 19 | +3 | 25 |
| 7 | Cambuur | 15 | 8 | 0 | 7 | 27 | 35 | -8 | 24 |
| 8 | AZ | 15 | 7 | 2 | 6 | 28 | 21 | +7 | 23 |
| 9 | Heerenveen | 15 | 6 | 3 | 6 | 18 | 21 | -3 | 21 |
| 10 | Go Ahead Eagles | 15 | 6 | 2 | 7 | 19 | 25 | -6 | 20 |
| 11 | NEC | 15 | 5 | 4 | 6 | 20 | 24 | -4 | 19 |
| 12 | Groningen | 15 | 4 | 6 | 5 | 17 | 21 | -4 | 18 |
| 13 | Willem II | 15 | 5 | 3 | 7 | 16 | 28 | -12 | 18 |
| 14 | RKC Waalwijk | 15 | 3 | 6 | 6 | 16 | 23 | -7 | 15 |
| 15 | Heracles Almelo | 15 | 4 | 2 | 9 | 15 | 21 | -6 | 14 |
| 16 | Sparta Rotterdam | 15 | 2 | 4 | 9 | 12 | 24 | -12 | 10 |
| 17 | Fortuna Sittard | 15 | 2 | 3 | 10 | 16 | 39 | -23 | 9 |
| 18 | PEC Zwolle | 15 | 1 | 3 | 11 | 8 | 27 | -19 | 6 |
Результаты
| Sunday, December 5, 2021 | ||
| Feyenoord | 5 - 0 | Fortuna Sittard |
| Go Ahead Eagles | 1 - 2 | Twente |
| AZ | 3 - 1 | Sparta Rotterdam |
| RKC Waalwijk | 2 - 1 | NEC |
| Saturday, December 4, 2021 | ||
| Heracles Almelo | 0 - 1 | Heerenveen |
| Cambuur | 1 - 6 | Vitesse |
| PSV Eindhoven | 4 - 1 | Utrecht |
| Friday, December 3, 2021 | ||
| Groningen | 1 - 1 | PEC Zwolle |
| Thursday, December 2, 2021 | ||
| Ajax | 5 - 0 | Willem II |
| AZ | 2 - 1 | Fortuna Sittard |
Следующий тур
| Friday, December 10, 2021 | ||
| Willem II | 19:00 | Cambuur |
| Saturday, December 11, 2021 | ||
| Utrecht | 17:45 | Go Ahead Eagles |
| Heerenveen | 19:00 | Sparta Rotterdam |
| PEC Zwolle | 20:00 | Fortuna Sittard |
| Sunday, December 12, 2021 | ||
| Twente | 11:15 | RKC Waalwijk |
| Groningen | 13:30 | Feyenoord |
| Vitesse | 13:30 | Heracles Almelo |
| Ajax | 15:45 | AZ |
| NEC | 19:00 | PSV Eindhoven |
| Saturday, December 18, 2021 | ||
| Fortuna Sittard | 15:30 | Utrecht |