| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Zenit | 11 | 7 | 2 | 2 | 23 | 14 | +9 | 23 |
| 2 | Sochi | 11 | 7 | 0 | 4 | 17 | 12 | +5 | 21 |
| 3 | Dinamo Moscow | 11 | 6 | 2 | 3 | 16 | 11 | +5 | 20 |
| 4 | CSKA Moscow | 11 | 6 | 2 | 3 | 14 | 8 | +6 | 20 |
| 5 | Lokomotiv Moscow | 11 | 4 | 6 | 1 | 15 | 10 | +5 | 18 |
| 6 | Krasnodar | 11 | 5 | 3 | 3 | 18 | 10 | +8 | 18 |
| 7 | Spartak Moscow | 11 | 5 | 2 | 4 | 13 | 10 | +3 | 17 |
| 8 | Krylya Sovetov | 11 | 5 | 1 | 5 | 14 | 13 | +1 | 16 |
| 9 | Rubin Kazan | 11 | 4 | 3 | 4 | 15 | 13 | +2 | 15 |
| 10 | Nizhny Novgorod | 11 | 4 | 2 | 5 | 12 | 15 | -3 | 14 |
| 11 | Akhmat Grozny | 11 | 4 | 0 | 7 | 11 | 18 | -7 | 12 |
| 12 | Arsenal Tula | 11 | 3 | 3 | 5 | 14 | 20 | -6 | 12 |
| 13 | Khimki | 11 | 2 | 5 | 4 | 10 | 15 | -5 | 11 |
| 14 | Ural | 11 | 2 | 3 | 6 | 5 | 14 | -9 | 9 |
| 15 | Rostov | 11 | 2 | 3 | 6 | 15 | 23 | -8 | 9 |
| 16 | Ufa | 11 | 2 | 3 | 6 | 12 | 18 | -6 | 9 |
Результаты
| Sunday, October 17, 2021 | ||
| Krasnodar | 1 - 1 | Ufa |
| Khimki | 2 - 0 | Akhmat Grozny |
| Krylya Sovetov | 2 - 0 | Nizhny Novgorod |
| Ural | 0 - 1 | CSKA Moscow |
| Saturday, October 16, 2021 | ||
| Sochi | 3 - 2 | Rostov |
| Spartak Moscow | 2 - 2 | Dinamo Moscow |
| Rubin Kazan | 2 - 2 | Lokomotiv Moscow |
| Arsenal Tula | 2 - 1 | Zenit |
| Sunday, October 3, 2021 | ||
| Lokomotiv Moscow | 1 - 2 | Rostov |
| Akhmat Grozny | 0 - 1 | Spartak Moscow |
Следующий тур
| Friday, October 22, 2021 | ||
| Dinamo Moscow | 16:00 | Khimki |
| Saturday, October 23, 2021 | ||
| Nizhny Novgorod | 11:00 | Krasnodar |
| Rostov | 13:30 | Arsenal Tula |
| CSKA Moscow | 16:00 | Krylya Sovetov |
| Sunday, October 24, 2021 | ||
| Ufa | 11:00 | Rubin Kazan |
| Akhmat Grozny | 13:30 | Ural |
| Zenit | 16:00 | Spartak Moscow |
| Monday, October 25, 2021 | ||
| Lokomotiv Moscow | 16:00 | Sochi |
| Friday, October 29, 2021 | ||
| Zenit | 16:00 | Dinamo Moscow |
| Saturday, October 30, 2021 | ||
| Rubin Kazan | 11:00 | CSKA Moscow |
