| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayern Munich | 8 | 6 | 1 | 1 | 29 | 8 | +21 | 19 |
| 2 | Borussia Dortmund | 8 | 6 | 0 | 2 | 22 | 14 | +8 | 18 |
| 3 | Bayer 04 Leverkusen | 8 | 5 | 1 | 2 | 21 | 12 | +9 | 16 |
| 4 | SC Freiburg | 8 | 4 | 4 | 0 | 12 | 6 | +6 | 16 |
| 5 | Union Berlin | 8 | 4 | 3 | 1 | 12 | 9 | +3 | 15 |
| 6 | Wolfsburg | 8 | 4 | 1 | 3 | 9 | 10 | -1 | 13 |
| 7 | FC Cologne | 8 | 3 | 3 | 2 | 13 | 14 | -1 | 12 |
| 8 | RB Leipzig | 8 | 3 | 2 | 3 | 16 | 8 | +8 | 11 |
| 9 | TSG 1899 Hoffenheim | 8 | 3 | 2 | 3 | 17 | 11 | +6 | 11 |
| 10 | Borussia Mönchengladbach | 8 | 3 | 2 | 3 | 10 | 11 | -1 | 11 |
| 11 | Mainz | 8 | 3 | 1 | 4 | 8 | 8 | +0 | 10 |
| 12 | Stuttgart | 8 | 2 | 3 | 3 | 13 | 14 | -1 | 9 |
| 13 | Hertha Berlin | 8 | 3 | 0 | 5 | 10 | 21 | -11 | 9 |
| 14 | Eintracht Frankfurt | 8 | 1 | 5 | 2 | 9 | 12 | -3 | 8 |
| 15 | VFL Bochum | 8 | 2 | 1 | 5 | 5 | 16 | -11 | 7 |
| 16 | Augsburg 1907 | 8 | 1 | 3 | 4 | 4 | 14 | -10 | 6 |
| 17 | Arminia Bielefeld | 8 | 0 | 5 | 3 | 4 | 11 | -7 | 5 |
| 18 | Greuther Fürth | 8 | 0 | 1 | 7 | 5 | 20 | -15 | 1 |
Результаты
| Sunday, October 17, 2021 | ||
| Augsburg 1907 | 1 - 1 | Arminia Bielefeld |
| Bayer 04 Leverkusen | 1 - 5 | Bayern Munich |
| Saturday, October 16, 2021 | ||
| Borussia Mönchengladbach | 1 - 1 | Stuttgart |
| Greuther Fürth | 0 - 1 | VFL Bochum |
| SC Freiburg | 1 - 1 | RB Leipzig |
| Union Berlin | 2 - 0 | Wolfsburg |
| Eintracht Frankfurt | 1 - 2 | Hertha Berlin |
| Borussia Dortmund | 3 - 1 | Mainz |
| Friday, October 15, 2021 | ||
| TSG 1899 Hoffenheim | 5 - 0 | FC Cologne |
| Sunday, October 3, 2021 | ||
| Arminia Bielefeld | 0 - 4 | Bayer 04 Leverkusen |
Следующий тур
| Friday, October 22, 2021 | ||
| Mainz | 18:30 | Augsburg 1907 |
| Saturday, October 23, 2021 | ||
| Bayern Munich | 13:30 | TSG 1899 Hoffenheim |
| RB Leipzig | 13:30 | Greuther Fürth |
| Wolfsburg | 13:30 | SC Freiburg |
| Arminia Bielefeld | 13:30 | Borussia Dortmund |
| Hertha Berlin | 16:30 | Borussia Mönchengladbach |
| Sunday, October 24, 2021 | ||
| FC Cologne | 13:30 | Bayer 04 Leverkusen |
| Stuttgart | 15:30 | Union Berlin |
| VFL Bochum | 17:30 | Eintracht Frankfurt |
| Friday, October 29, 2021 | ||
| TSG 1899 Hoffenheim | 18:30 | Hertha Berlin |
